01 / OVERVIEW
What it is
PT-141 (bremelanotide) is a peptide that activates melanocortin receptors in the brain. It was FDA-approved in 2019 to treat hypoactive sexual desire disorder (HSDD) in premenopausal women.
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PT-141
Bremelanotide
A peptide that works in the brain to increase sexual desire, rather than acting on blood flow.
- STATUS
- FDA-approved (brand-name injection) for low sexual desire (HSDD) in premenopausal women. Other uses and compounded forms are not FDA-approved.
- FORMS
- As-needed injection · Nasal spray or other compounded forms
- ACCESS
- Prescription only · Telehealth in all 50 states
KEY TAKEAWAYS
- Acts on melanocortin receptors in the brain involved in desire
- Taken as needed before sexual activity, not daily
- Different from medications that work on blood flow
02 / MECHANISM
How it works
Rather than increasing blood flow, bremelanotide is thought to influence the brain pathways involved in sexual desire and arousal. It is used on demand before anticipated sexual activity.
03 / EVIDENCE
What the research shows
In two phase 3 trials (RECONNECT), premenopausal women with HSDD who used bremelanotide reported modest but statistically significant improvements in desire and reduced distress compared with placebo. Use in men and postmenopausal women has been studied less and is considered off-label.
04 / FIT
Who it may help
- Premenopausal women with persistent low desire that causes distress
- Adults whose concern is desire rather than physical function
- Patients without uncontrolled blood pressure or heart disease
05 / CAUTION
Who should avoid it
- Uncontrolled high blood pressure or known cardiovascular disease
- Pregnancy
- Taking naltrexone by mouth (may reduce its effect)
06 / SAFETY
Possible side effects
- Nausea — the most common side effect, usually after the first doses
- Flushing, headache, or injection-site reactions
- Temporary increase in blood pressure and decrease in heart rate
- Darkening of skin or gums with repeated use
This is not a complete list. Your provider will review risks, benefits, and alternatives with you before starting any treatment.
QUESTIONS
Good to know.
Is PT-141 like Viagra? +
No. Medications like sildenafil act on blood flow; PT-141 works in the brain on desire.
How often can it be used? +
Use is limited and as needed. Your provider will explain safe use for your situation.
Can men use it? +
Use in men is off-label and less studied. Your provider can discuss whether it may be appropriate.
How do I get started? +
Complete a short Get Started form. A licensed provider in your state will review your goals and history by telehealth, order labs if needed, and decide whether PT-141 or another option is appropriate.
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EDUCATIONAL INFORMATION
This page is for general education and is not medical advice. PT-141 requires a prescription and is provided only after evaluation by a licensed provider when appropriate. When a compounded formulation is prescribed, it is prepared by a licensed U.S. pharmacy for you specifically. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness, or quality.