GET STARTEDPEPTIDE THERAPY / WEIGHT MANAGEMENT
A once-weekly GLP-1 medication that helps regulate appetite and blood sugar, used as part of a medical weight-management plan.
KEY TAKEAWAYS
01 / OVERVIEW
Semaglutide is a GLP-1 receptor agonist — a lab-made version of glucagon-like peptide-1, a hormone your gut releases after eating. It was first approved for type 2 diabetes and later for chronic weight management in adults who meet certain criteria.
02 / MECHANISM
GLP-1 acts on the brain's appetite centers to increase feelings of fullness and reduce hunger, slows how quickly the stomach empties, and helps the pancreas release insulin when blood sugar rises. Together, these effects make it easier to eat less without constant hunger.
03 / EVIDENCE
In the STEP 1 trial, adults with obesity (without diabetes) who took weekly semaglutide alongside lifestyle changes lost about 15% of their body weight on average over 68 weeks, compared with about 2% on placebo. The SELECT trial later found a lower rate of major cardiovascular events in adults with established heart disease and overweight. Weight often returns if treatment stops, so plans are built for the long term.
04 / FIT
05 / CAUTION
06 / SAFETY
This is not a complete list. Your provider will review risks, benefits, and alternatives with you before starting any treatment.
QUESTIONS
Many people notice less hunger within the first few weeks. Weight change is gradual — your provider adjusts the plan over several months based on how you respond and how you feel.
Often, yes. Baseline labs help your provider confirm the medication is appropriate and give a starting point to measure progress.
Appetite effects fade after stopping, and weight can return. Your provider will talk through a long-term plan, including how to maintain results.
Complete a short Get Started form. A licensed provider in your state will review your goals and history by telehealth, order labs if needed, and decide whether Semaglutide or another option is appropriate.
KEEP LEARNING
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This page is for general education and is not medical advice. Semaglutide requires a prescription and is provided only after evaluation by a licensed provider when appropriate. When a compounded formulation is prescribed, it is prepared by a licensed U.S. pharmacy for you specifically. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness, or quality.